教授、主任医师
医学博士,博士后,血液病学专家,博士研究生导师。
1. SCI 杂志 Anti-Cancer Drugs 编委( 2009 年 IF:2.23 )。
2. 教育部“中国科技论文在线”特邀评审专家。
3. British Journal of Hematology 、 International Journal of Cancer 、 Oncology 等多种杂志审稿人。
4. 国家自然科学基金及广东省自然科学基金评审专家。
5. 欧洲肿瘤协会抗癌分会国际会员。
6. 广东省中西医结合学会常委。
7. 广州市抗癌协会血液肿瘤分会常委。
获奖情况
1.2004 年荣获中山大学附属三院优秀中青年医师奖,是中山大学“千百十人才工程”培养对象。
2. 2006-2007 年以来被美国 Who\'s who in The Medicine and Healthcare (世界医学与健康护理名人录)收录。
3. 2006 年被评为教育部“新世纪优秀人才”。
4. 2008 及 2009 年教育部“科技论文在线”优秀通讯评审专家。
论 著:截至到目前为止,在国内外核心期刊发表学术论文 50 余篇 ( 第一作者 ), 其中 SCI 收录 20 余篇。
以第一或通讯作者发表的主要代表论文(均为 SCI 收录)有:
1. Antibody directed lentiviral mediated double suicide gene therapy in MUC-1 positive leukemia in vitro and in vivo. Cell Transplant 2011(In Press)
2. PPARγ Agonist Suppresses TLR4 Expression and TNF-α Production in LPS Stimulated Monocyte Leukemia Cells. Cell Biochem Biophys . 2010 Nov 23. [Epub ahead of print] ( 通讯作者 ) 。
3. Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro. Annals of Hematology 2010; 89(5):1089–1097. (通讯作者)
4. Down-Regulation of Telomerase Activity and Activation of Caspase Are Responsible for Tanshinone I-Induced Apoptosis in Monocyte Leukemia Cells. International Journal of Molecular Sciences 2010; 11(5): 2267-2280.
5. Activation of peroxisome proliferator-activated receptor-gamma induces apoptosis on acute promyelocyti leukemia cells via downregulation of XIAP. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2009; 24(5): 623-632.
6. Peroxisome Proliferator-Activated Receptor γ (PPAR-γ) Agonist Rosiglitazone (RGZ) Inhibits HL-60 Cell Growth by Induction of Apoptosis. Lab Medicine 2009; 40(5):297-302.
7. Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis. Oncology Reports 2009; 21(3): 1075-1081.
8. Peroxisome Proliferator-Activated Receptor-g Agonist Rosiglitazone–Induced Apoptosis in Leukemia K562 Cells and Its Mechanisms of Action. International Journal of Toxicology 2009; 28(2):123-131.
9. Ponicidin Inhibits Monocytic Leukemia Cell Growth by Induction of Apoptosis. International Journal of Molecular Sciences 2008 ; 9(11) : 2265-2277.
10. Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. Annals of Hematology 2007;86 (3):173-183.
11. Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. Journal of Biomedical Science 2006; 13(12):813–823.
12. Antiproliferation Effects of Oridonin on HPB-ALL Cells and Its Mechanisms of Action. American Journal of Hematology 2006; 81(2):86–94.
13. Ponicidin, an Ent-Kaurane Diterpenoid Derived from a Constituent of the Herbal Supplement PC-SPES, Rabdosia rubescens , Induces Apoptosis by Activation of Caspase-3 and Mitochondrial Events in Lung Cancer Cells In Vitro. Cancer Investigation 2006; 24(2):136–148.
14. Expression of survivin and bax/bcl -2 in peroxisome proliferator activated receptor-{gamma} ligands induces apoptosis on human myeloid leukemia cells in vitro . Annals of Oncology 2005; 16(3):455-459.
15. Peroxisome proliferator activated receptor- ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. Cancer Chemotherapy and Pharmacology 2005;56(4):400-408.
16. Oridonin-induced apoptosis in leukemia K562 cells and its mechanism. Neoplasma 2005;52 (3):225-230.
17. Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro . Oncology Reports 2005; 13 (4):653-657.
18. Apoptotic effect of oridonin on NB4 cells and its mechanism. Leukemia & Lymphoma 2005; 46 (4): 593-597.
19. Antiproliferation effects of oridonin on HL-60 cells. Annals of Hematology 2004; 83(11):691-695.
20. Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action. Journal of International Medical Research 2004; 32 (6):617-625.
21 . Oridonin Inhibit Cell Growth by Induction of Apoptosis on Human Carcinoma BEL7402 Cells.Hepatology Research . 2006;35(2)104-110.
22 . Oridonin-induced apoptosis of Jurkat cells and its mechanism. Comparative Pathology.2004;13(2): 65-69.
从事内科血液学临床医疗及科研工作近20年。多年以来从事白血病细胞凋亡
信号转导机制、血液肿瘤的分子靶向治疗及抗白血病药物的作用靶点等研究。 目
前担任欧洲国际著名SCI杂志 Anti-Cancer Drugs(2005年最新影响因子为:2.05)
编委(Editorial borad), 国家自然科学基金委评审专家、 广东省自然基金委评审
专家。现为美国血液学会会员,欧洲肿瘤协会抗癌分会国际会员,多年以来担任
British Journal of Hematology,International Journal of Cancer,Oncology
等著名SCI杂志特约审稿人(Peer Reviewer)。曾经参与完成国家自然科学基金
2项,省自然科学基金4项。
截至到目前为止,在国内外核心期刊发表论文50余篇(第一作者), 其中SCI收
录14篇。 2006-2007年以来被美国 Who\'s who in The Medicine and Healthcare
(世界医学与健康护理名人录)收录。 2004年荣获中山大学附属三院优秀中青年医
师奖。是中山大学“千百十人才工程”培养对象。 2006年科研课题荣获教育部“新
世纪优秀人才支持计划”资助。 多年来发表的一系列研究成果被国际医学权威研究
机构 complementary and Alternative Medicine Research 收录。